Using Petri Nets to Model the Chemical Stages of the Radiobiological Mechanism


Jiří Barilla
J. E. Purkinje University in Usti Nad Labem, Faculty of Science, České Mládeže 8, Czech Republic

Miloš V. Lokajíček
Academy of Sciences of the Czech Republic, Prague, Czech Republic

Hana Pisaková
Academy of Sciences of the Czech Republic, Prague, Czech Republic

Pavel Simr
J. E. Purkinje University in Usti Nad Labem, Faculty of Science, České Mládeže 8, Ústí nad Labem, Czech Republic

Series: Medicine and Biology Research Developments
BISAC: SCI008000

This book presents new developments in the study of the chemical stage of a radiobiological mechanism. The biological effect of ionizing particles in diploid cells depends on their linear energy transfer (LET) value. While for low-LET particles a pair of DSBs in the same sections of both the equal DNA molecules is to be formed by different particles in a relatively short irradiation interval, the increase of these DSB pairs at higher LET values is given by singular particles. This means that the radiobiological mechanism in physical and biological stages may be understood at least in principle, while the chemical stage represents a still rather open problem. It concerns basic process running in this stage as well as the influence of radiomodifying agents being present in a corresponding water medium during irradiation (mainly for low-LET radiation), which may be important in the regions of radiotherapy as well as radioprotection.

It has been commonly assumed that this stage has been mediated by radical clusters formed by a densely ionizing end of secondary electrons. It is evident that only greater radical clusters (being able to form at least two SSBs in a given DNA molecule) may be efficient biologically. These clusters may originate, however, at different distances from DNA molecules present in a cell; they may meet a certain time after (due to heat motion and cluster diffusion). Consequently, the resulting biological effect may be influenced also by chemical processes running in diffusing clusters. A new model of corresponding cluster evolution (based on the use of a continuous Petri net and describing the concurrent influence of cluster diffusion and corresponding chemical reactions) will be presented and the possibility of its use in the analysis of a biological stage will be shown. On the basis of available data, the initial cluster characteristics (the emergence of water radicals) as well as the emergence of other radicals (if corresponding agents are present) may be established. The corresponding influence on the processes running in a biological stage may be estimated as well.



Table of Contents

Chapter 1. Introduction

Chapter 2. The Mechanism of the Radiobiological Effect

Chapter 3. The Influence of Oxygen and N2O on DNA Damage by Ionizing Particles

Chapter 4. The Chemical Stage and DSB Formation in Chromosomes

Chapter 5. Chemical Stage Simulation Using Continuous Petri Nets

Chapter 6. Analysis of Subsequent Mechanisms in Cells

Chapter 7. Conclusion



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